Anti-2SC antibody

Cat#CRB2005017_3

簡(jiǎn)介：
琥珀酸是半胱氨酸殘基的一種穩(wěn)定的翻譯后修飾，其會(huì)改變蛋白質(zhì)功能或轉(zhuǎn)變以響應(yīng)細(xì)胞內(nèi)氧化還原環(huán)境的變化。當(dāng)Krebs循環(huán)中間體富馬酸鹽與半胱氨酸反應(yīng)產(chǎn)生S-（2-琥珀酸）半胱氨酸（2SC）時(shí)，就會(huì)發(fā)生丁二酸。大量的蛋白質(zhì)會(huì)發(fā)生琥珀酸化，包括酶、脂肪因子、細(xì)胞骨架蛋白和ER伴侶，琥珀酸化已被證明在調(diào)節(jié)生物學(xué)中發(fā)揮作用。在糖尿病中可以看到脂肪細(xì)胞蛋白琥珀化的增加，這是由營(yíng)養(yǎng)過剩引起的線粒體應(yīng)激引起的。因此，2SC被作為慢性疾病（如肥胖、糖尿病和癌癥）中線粒體應(yīng)激或功能障礙的生物標(biāo)志物。
產(chǎn)品描述：

貨號(hào)	CRB2005017e/6773
宿主	兔
緩沖液	TEA洗脫液
免疫原	S-(2-succinyl)-cysteine-KLH 標(biāo)記
濃度	1mg/ml
規(guī)格	50ul
應(yīng)用	WB, ELISA, IHC
推薦稀釋比	WB (1:200), ELISA (I:1000), IHC (1:2000)
保存	≤-15℃
結(jié)果示例	Fig1. 腎癌中2SC的細(xì)胞質(zhì)染色呈陽性
引用文獻(xiàn)	Alderson, N. et al. (2006) S-(2-Succinyl)cysteine: A novel chemical modification of tissue proteins by a Krebs cycle intermediate. Arch Biochem Biophys, 450(1), 1-8. PMID: 16624247   Nagai, R. et al. (2007) Succination of Protein Thiols during Adipocyte Maturation: a biomarker of mitochondrial stress. J Biol Chem, 282(47), 34219-34228. PMID: 17726021   Merkley, E et al. (2013) The succinated proteome. Mass Spectrom Rev, 33(2), 98-109. PMID: 24115015   Burgener et al., (2019). SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2. Nat Immunol. 20(10):1311-1321. PMID: 31527833 Casey et al., (2020). Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans.Clin Cancer Res.  26(2):391-396. PMID: 31636096. doi: 10.1158/1078-0432. Gupta et al., (2020). Secondary Renal Neoplasia Following Chemotherapy or Radiation in Pediatric Patients. Hum Pathol.  PMID: 32681944. doi: 10.1016/j.humpath.2020.07.014. ?yr?v?inen et al., (2020). Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy. Human Reproduction. deaa187,

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